Application of 39538-68-6, A common heterocyclic compound, 39538-68-6, name is 2-Methoxy-4-methylaniline, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(Step 1)Synthesis of 2-methoxy-4-methylphenyl isothiocyanate (compound represented by formula (b)) N 1,1′-thiocarbonyldiimidazole (6.10 g), N-dimethylformamide (80 ml) solution, at room temperature, 2-methoxy-4-N methyl aniline (3.43 g), N-dimethylformamide solution (40 ml) was added and stirred for 1 hour. Then water was added at 0 , and extracted with ethyl acetate. The organic layer was washed with water, then washed with saturated brine. Then, the organic layer was dried over anhydrous magnesium sulfate, filtered, then concentrated in vacuo. The resulting crude product was purified by silica gel column chromatography, to obtain the desired product (4.53g).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; NIPPONSODA COMPANY LIMITED; SHIMIZU, KAZUYA; SAKAMOTO, RIE; TAKAHASHI, JUN; KANAZAWA, JYUN; (37 pag.)JP2016/29022; (2016); A;,
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