Adding a certain compound to certain chemical reactions, such as: 156573-09-0, name is 1-Bromo-4-ethoxy-2,3-difluorobenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 156573-09-0, category: ethers-buliding-blocks
Under a nitrogen atmosphere,60 g of trimethylsilylacetylene,120 g of 4-ethoxy-2,3-difluorobromobenzene, 1.9 g of copper iodide,11.7 g of tetrakistriphenylphosphine palladium were dissolved in 500 mL of DMF,And the mixture was stirred at 70 C. for 2 hours.To the reaction mixture were added toluene,Add water,After stirring, the organic layer was separated.The organic layer was washed with waterwater,Ammonia water,Followed by washing with saturated saline in this order,After drying with anhydrous sodium sulfate,The solvent was distilled off under reduced pressure.The obtained crystalRecrystallization and purification by column chromatography (silica gel)120 g of trimethyl- (4-ethoxy-2,3-difluorophenylethynyl) silane was obtained.
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Reference:
Patent; DIC CORPORATION; NOSE, SAYAKA; SAITOU, YOSHITAKA; KADOMOTO, YUTAKA; (18 pag.)JP5696874; (2015); B2;,
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