Application of 148583-65-7, These common heterocyclic compound, 148583-65-7, name is 4-Fluoro-2-isopropoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 1 5-Ethyl-N-(4-fluoro-2-isopropoxy^henyl)pyrrolo[3,2-d]pyrimidin^ 2-isopropoxy-4-fluoroaniine (55mg, 0.33mmol), Intermediate 2 (54mg, 0.30mmol), 4M HCi in dioxane (0.1ml) and IPA (2ml) were heated in the microwave at 140C for 20 min. The mixture was concentrated and purified by preparative LCMS to give a white solid (41 mg, 44%); 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 1.43 (d, J=6.0 Hz, 6 H), 1.61 (t, J=7.3 Hz, 3 H), 4.45 (q, J=7.3 Hz, 2 H), 4.68 (spt, J=6.0 Hz, 1 H), 6.60 (d, J=3.2 Hz, 1 H), 6.69 (dd, J=10.0, 2.7 Hz, 1 H), 6.75 (td, J=8.7, 2.7 Hz, 1 H), 7.24 (d, J=3.2 Hz, 1 H), 7.58 (br. s, 1 H), 8.54 (s, 1 H), 8.75 (dd, J=8.9, 6.2 Hz, 1 H); LC-MS (ESI): (MH+) 315.2
The synthetic route of 148583-65-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MEDICAL RESEARCH COUNCIL TECHNOLOGY; WINTER-HOLT, Jon James; MCIVER, Edward Giles; LEWIS, Stephen; OSBORNE, Joanne; (106 pag.)WO2017/85483; (2017); A1;,
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