Electric Literature of 332-48-9,Some common heterocyclic compound, 332-48-9, name is 1-(2-Bromoethoxy)-4-fluorobenzene, molecular formula is C8H8BrFO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixtureof 4,5-dichloroimidazole (Ia) (1.37 g, 10 mmol)and finely ground KOH (10 mmol, taking intoaccount the 85% content) in DMSO (7 mL) wasstirred at 35 C for 15 min, followed by the addition of2-aryloxybromide (11 mmol) at such a rate that thereaction temperature did not exceed 50C. The reactionoccurred for 30 min at 45C. After cooling, water(40 mL) was gradually added, and the resulting voluminousprecipitate of 1-aryloxyethyl-substitutedimidazoles (IIf)-(IIn) were filtered and washed with5% KOH (2 mL) and water.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(2-Bromoethoxy)-4-fluorobenzene, its application will become more common.
Reference:
Article; Kovalenko; Divaeva; Zubenko; Morkovnik; Drobin; Fetisov; Bodryakov; Dorofeenko; Russian Journal of Bioorganic Chemistry; vol. 42; 5; (2016); p. 551 – 559; Bioorg. Khim.; vol. 42; 5; (2016); p. 608 – 616,9;,
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