Electric Literature of 13468-02-5,Some common heterocyclic compound, 13468-02-5, name is N,N-Dimethyl-2-phenoxyethanamine, molecular formula is C10H15NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The oil XI 132g (0.8mol), 30% concentrated hydrochloric acid 195g (1.6mol) was dissolved in 400ml of water with stirring, at -10 temperature or less, 40% formaldehyde was slowly added dropwise a solution of 40g (0.8mol) reaction was continued for 2 hours; TLC monitoring completion of the reaction, the pH was adjusted to 8 with sodium carbonate to 9, and extracted twice with dichloromethane, organic phases were combined and concentrated to give an oil, 300ml ethyl acetate was added to dissolve,Was added dropwise 30% HCl / ethanol, precipitated crystals were filtered to give 112.7g compound XII, a yield of 56.3%;
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N,N-Dimethyl-2-phenoxyethanamine, its application will become more common.
Reference:
Patent; Weihai Di Su Pharmaceutical Co., Ltd.; Wu, Ronggui; Jiang, Kai; An, Donghua; Cui, Yangyang; Men, Lianbin; (7 pag.)CN105985257; (2016); A;,
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