Related Products of 148583-65-7,Some common heterocyclic compound, 148583-65-7, name is 4-Fluoro-2-isopropoxyaniline, molecular formula is C9H12FNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1: Phosgene (20% in toluene; 63 mL, 118.2 mmol, 2 equiv) was cooled to – 10 C (ice/MeOH) under argon. Then 4-fluoro-2-isopropoxybenzenamine (10.0 g, 59.1 mmol, 1 equiv) was added drop wise, and the reaction mixture was stirred at -10 C for 15 min then heated to 90 C for 3 h under argon. After cooling, the reaction mixture was evaporated to dryness, and the crude 4-fluoro-l-isocyanato-2-isopropoxybenzene was dried in vacuo.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Fluoro-2-isopropoxyaniline, its application will become more common.
Reference:
Patent; RIGEL PHARMACEUTICALS, INC.; SINGH, Rajinder; DUNCTON, Matthew; ZHANG, Jing; ALVAREZ, Salvador; TSO, Kin; HOLLAND, Sacha; YEN, Rose; KOLLURI, Rao; HECKRODT, Thilo; CHEN, Yan; MASUDA, Esteban; LI, Hui; PAYAN, Donald G.; KELLEY, Ryan; WO2013/152198; (2013); A1;,
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