Synthetic Route of 37466-89-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 37466-89-0 name is 3-Methoxybenzene-1,2-diamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
13.1 r3-(2-Amino-3-methoxy-phenylcarbamoyl)-propyll-methyl-carbamic acid benzyl esterTo a solution of 1.40 g 4-(benzyloxycarbonyl-methyl-amino)-butyric acid (obtained from 4- (methylamino)butyric acid and benzylchloroformate) in 25 mL THF were added 2.9 mL of DIPEA, 0.97 g of HOBt and 1.38 g EDC. After stirring for 5 min 0.80 g of 3-methoxy- benzene-1 ,2-diamine were added and the mixture was stirred for 3 h at rt. Sat. aq. NaHCOs solution was added, the phases were separated and the organic phase was washed with brine. The combined organic phases were dried over MgSO4, and concentrated in vacuo.LC-MS (A): tR = 0.80 min; [M+H]+: 372.27.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Methoxybenzene-1,2-diamine, and friends who are interested can also refer to it.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; HILPERT, Kurt; HUBLER, Francis; RENNEBERG, Dorte; WO2010/46855; (2010); A1;,
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