Reference of 82830-49-7, The chemical industry reduces the impact on the environment during synthesis 82830-49-7, name is 2-Fluoro-1,4-dimethoxybenzene, I believe this compound will play a more active role in future production and life.
To a stirred solution of 2-fluoro-l,4-dimethoxybenzene (500 mg, 3.2 rnmol) in THF (10 mL) at -78 0C was added dropwise a 2.5M solution of n-BuLi in hexane (1.28 mL, 3.2 mmol). The reaction mixtured was stirred for Ih, and then DMF (0.27 mL, 3.5 mmol) was added at such a rate as to keep the temperature below -70 0C. Upon completion of addition, the reaction mixture was stirred for 3h and then quenched at -78 by addition of a solution of acetic acid (“HOAc”) in THF. Water was added and the reaction mixture was extracted with ethyl acetate. The organic extracts were dried over MgSO4, filtered, and the solvent was removed under reduced pressure to provide Intermediate 20 as a yellow solid (518 mg, 88%), which was used without further purification.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Fluoro-1,4-dimethoxybenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2007/30582; (2007); A2;,
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