Synthetic Route of 886762-08-9, The chemical industry reduces the impact on the environment during synthesis 886762-08-9, name is 5-Bromo-2-(trifluoromethoxy)aniline, I believe this compound will play a more active role in future production and life.
General procedure: Triphosgene (0.74 g, 2.5 mmol) was dissolved in anhydrousCH2Cl2 (20 mL) and the mixture was stirred on the ice-bath for15 min. A solution of the [3-bromo-5-(trifluoromethyl)phenyl]amine (1.66 g, 6.9 mmol) in anhydrous CH2Cl2 (10 mL) was addeddropwise to the above mixture and stirring continued for 30 min.Then triethanolamine (0.75 mL, 5.5 mmol) diluted with CH2Cl2(10 mL) was then added into the mixture. Stirring was continuedfor 20 min, a solution of triethanolamine (0.75 mL, 5.5 mmol) andintermediate (4a) (1.50 g, 6.3 mmol) in anhydrous CH2Cl2 (10 mL)was added. After completion of the action, the reaction wasquenched with dilute NaHCO3. The organic layer was washed withwater and brine, and dried over Na2SO4. After filtration and concentrationin vacuo, the residues was purified by silica gel flash chromatography (PE/AcOEt 5:1) gave as white solid (5a) (1.36 g,43%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-2-(trifluoromethoxy)aniline, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Shan, Yuanyuan; Gao, Hongping; Shao, Xiaowei; Wang, Jinfeng; Pan, Xiaoyan; Zhang, Jie; European Journal of Medicinal Chemistry; vol. 103; (2015); p. 80 – 90;,
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