In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 437-82-1, name is 2,6-Difluoroanisole belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 2,6-Difluoroanisole
500 ml dry reaction flask, replaced with nitrogen gas, was added the compound (IV) 28.8 g of 100 ml of anhydrous 2-methyltetrahydrofuran, in the system under a nitrogen atmosphere, stirred and cooled to -78C, and slowly added dropwise 1.6M n-hexane solution of n-butyllithium in 185 ml. after completion of the dropwise addition, at -60 ~ -50C reaction was stirred for 2 hours.System cooling to -78C, carbon dioxide gas through for 5 hours after completion through ~ -40 -30C was stirred for 3 hours.The reaction system was allowed to warm to room temperature, 200 ml of water, stirred, and the organic solvent is recovered by distillation under reduced pressure, and the residue with 36% hydrochloric acid, filtered, and the filter cake washed with 100 ml of water, dried to give compound (V) 31.6 g.
The synthetic route of 437-82-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ZHEJIANG ZHONGXIN FU CAI CO LTD/ ZHEJIANG ZHONGXIN CHEMICALS CO., LTD.; YUAN, QILIANG; ZHANG, JIABING; XU, PENGFEI; JIANG, XIANBO; CHEN, YINHAO; WANG, CHAO; (16 pag.)CN103819401; (2016); B;,
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