Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2688-84-8, name is 2-Phenoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2-Phenoxyaniline
Stage 2 (i) 2- amino diphenyl ether from (1.80g, 9.8mmol) and 2-methoxy-3-pyridine carboxaldehyde (2.0g, 14.6mmol) in a mixture 90 under hydrogen with 1h . The reaction mixture was cooled to 0 C., was added MeOH (20mL), then sodium borohydride (1.11g, 29.4mmol) was added over 20 minutes in small portions. The mixture was stirred for 24 h at RT. It was added formic acid (2.4g, 53.0mmol), and the mixture was stirred for 15 minutes. The solvent was removed in vacuo, the residue was quenched with 10% aqueous sodium bicarbonate (100 mL), and extracted with DCM (2 × 30mL), dried over magnesium sulfate, filtered and the solvent in vacuo It was removed. The crude material DCM (A): silica gel chromatography eluting with ethyl acetate (B) was obtained (2% (B), 80g, 2.0CV, 60mL / min) The impure product is purified by. Samples By crystallization from methanol, 2.2 g (73%) of (2-methoxy-pyridin-3-ylmethyl)-(2-phenoxy-phenyl)amine as a white solid
According to the analysis of related databases, 2688-84-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GE HEALTHCARE LIMITED; WADSWORTH, HARRY JOHN; TRIGG, WILLIAM JOHN; (36 pag.)JP5787873; (2015); B2;,
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