Synthetic Route of 24332-20-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 24332-20-5 as follows.
To a solution of 1,1,2-trimethoxy-ethane (25.0 g, 208.07 mmol) in methanol (125 mL) was added NH2OH.HCl (14.45 g, 208.07 mmol) at 0 C. The mixture was stirred for 16 h at room temperature. The mixture was cooled to 10 C. and aqueous NaOH solution (8.32 g, 208 mmol in 65 mL water) was added. The mixture was then stirred for 4 h at room temperature. The mixture was concentrated in vacuo and the remanence extracted with EtOAc (2×100 mL). The combined organic layers were dried over Na2SO4 and evaporated to dryness to give the crude oxime as a pale yellow liquid (12.0 g, 62%).
According to the analysis of related databases, 24332-20-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; H. Lundbeck A/S; US2012/252853; (2012); A1;,
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