Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 37895-73-1, name is 1,2-Dibromo-4,5-dimethoxybenzene, A new synthetic method of this compound is introduced below., Application In Synthesis of 1,2-Dibromo-4,5-dimethoxybenzene
a) Preparation of 4′,5′-Dimethoxy-[1,1′:2′,1″-terphenyl]-4,4″-dicarbonitrile A flask containing 4,5-dibromoveratrole (407 mg, 1.375 mmol), 4-cyanophenylboronic acid (606 mg, 4.125 mmol), Pd(PPh3)4 (159 mg, 0.1375 mmol), and Na2CO3 (729 mg, 6.875 mmol) was degassed and dioxane (6 mL) and H2O (3 mL) were added. Reaction was refluxed at 102 C. overnight then cooled to RT and diluted with EtOAc. Solution was washed with saturated NaHCO3 solution followed by brine and organic layer was collected, dried over Na2SO4, and concentrated. Chromatography using ISCO max gradient 50% EtOAc/hexane yielded product as a light yellow solid (467 mg, quantitative); 1H NMR (400 MHz) (CDCl3) delta 7.46-7.44 (m, 4H), 7.14-7.12 (m, 4H), 6.83 (s, 2H), 3.89 (s, 6H); 13C NMR (100 MHz) (CDCl3) delta 149.4, 145.6, 132.0, 131.3, 130.6, 118.7, 113.5, 110.6, 56.2.
The synthetic route of 37895-73-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; LaVoie, Edmond J.; Arnold, Eddy; Bauman, Joseph D.; Kerrigan, John E.; Parhi, Ajit K.; Das, Kalyan; Kelley, Cody; Patel, Dishaben V.; US2015/322022; (2015); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem