19500-02-8, name is 3-Methoxy-2-methylaniline, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 3-Methoxy-2-methylaniline
General procedure: Ammonium thiocyanate was added to a solution of aniline in 1.0 N HCl(aq). The reaction was stirred at 100 C for 16 h-20 h,cooled to room temperature over 1 h, diluted with cold water(30 mL), and then neutralized with saturated NH4OH(aq) (pH > 7).The precipitatewas collected by vacuum filtration andwashed withwater and diethyl ether: n-hexanes (1: 3) to give the desiredproduct. The product was purified by Isco Combi-Flash Companioncolumn chromatography.
The synthetic route of 19500-02-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Lin, Shu-Yu; Kuo, Yu-Hsien; Tien, Ya-Wen; Ke, Yi-Yu; Chang, Wan-Ting; Chang, Hsiao-Fu; Ou, Li-Chin; Law, Ping-Yee; Xi, Jing-Hua; Tao, Pao-Luh; Loh, Horace H.; Chao, Yu-Sheng; Shih, Chuan; Chen, Chiung-Tong; Yeh, Shiu-Hwa; Ueng, Shau-Hua; European Journal of Medicinal Chemistry; vol. 167; (2019); p. 312 – 323;,
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