Some common heterocyclic compound, 126829-31-0, name is 2-Ethynyl-1,3-dimethoxybenzene, molecular formula is C10H10O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C10H10O2
General procedure: 1 ethynyl 2-methoxybenzene (2a) (265 mg, 2 mmol) and phenylazide (238 mg, 2 mmol) were added in 8 mL of a water and tertbutanol(1:1) mixture. Then 200 mL of freshly prepared 1 M aq.solution of sodium ascorbate (0.2 mmol) was added, following theaddition of 65 mL of aq. CuSO4*5H20 (5 mg, 0.02 mmol) solution. Thereaction mixture was stirred for approximately 14 h at room temperatureand reaction progress was monitored by TLC until its reactantswere completely consumed. Then 30 mL of ice cold waterwas poured into the reaction mixture and flask put in ice bath for15 min following the filtration to get white precipitate that werethoroughly rinsed with cold water (2 x 15 mL). The collected solidwas dried under vacuum to get pure product [23,24].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 126829-31-0, its application will become more common.
Reference:
Article; Jabeen, Sobia; Khera, Rasheed Ahmad; Iqbal, Javed; Asgher, Muhammad; Journal of Molecular Structure; vol. 1206; (2020);,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem