Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 321-28-8, name is 1-Fluoro-2-methoxybenzene, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-Fluoro-2-methoxybenzene
A mixture of 2-fluoroanisole (1.78 mL, 15.9 mmol), cyclopropanecarbonitrile (4.68 mL, 63.6 mmol), and KHMDS (0.5 M solution in toluene, 50 mL, 24 mmol) was stirred and heated to 60 C. under N2. After 5 h, the mixture was allowed to cool to room temperature, then treated with 1 N HCl and extracted twice with toluene. The toluene extracts were combined, washed with brine, dried over Na2SO4, filtered, and the solvent was removed in vacuo. The oily residue was dissolved in CH2Cl2 and purified by chromatography on silica gel (gradient 3:1 hexanes/CH2Cl2 to CH2Cl2) to provide compound 6 (530 mg, 21%) as a clear, colorless oil: 1H NMR (300 MHz, CDCl3) delta 7.19-7.34 (m, 2H), 6.88-6.93 (m, 2H), 3.93 (s, 3H), 1.58-1.63 (m, 2H), 1.23-1.27 (m, 2H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Termin, Andreas; Grootenhuis, Peter D.J.; Wilson, Dean M.; Molteni, Valentina; Mao, Long; Castellino, Angelo; Yang, Zhicai; Pechulis, Anthony; Suto, Mark; US2003/229091; (2003); A1;,
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