Related Products of 4393-09-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4393-09-3, name is (2,3-Dimethoxyphenyl)methanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A solution of EXAMPLE 7A (175 mg) in acetonitrile (4 mL) at 25 C. was treated with 2,3-dimethoxybenzylamine (85 mg) and N,N-diisopropylethylamine (450 muL), heated in a microwave reactor for 10 min at 50 C., and 20 min at 195 C., cooled, treated with tert-butyl (1S,4S)-(-)-2,5-diaza-bicyclo(2.2.1)heptane-2-carboxylate (119 mg), heated in a microwave reactor for 20 min at 195 C., cooled, treated with water, acidified to pH 3 with aqueous HCl, and extracted with ethyl acetate. The extract was washed with water, and concentrated. A solution of the concentrate in ethanol (4 mL) at 25 C. was treated with LiOH (0.1M, 5 mL), stirred for 18 hours, treated with water, acidified to pH 1 with aqueous HCl, and filtered.
The synthetic route of (2,3-Dimethoxyphenyl)methanamine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Anderson, David; Beutel, Bruce; Bosse, Todd D.; Clark, Richard; Cooper, Curt; Dandliker, Peter; David, Caroline; Gu, Yu-Gui; Hansen, Todd Matthew; Hinman, Mira; Kalvin, Douglas; Larson, Daniel P.; Lynch, Linda; Ma, Zhenkun; Motter, Christopher; Palazzo, Fabio; Rosenberg, Teresa; Rehm, Tamara; Sanders, William; Tufano, Michael; Wagner, Rolf; Weitzberg, Moshe; Yong, Hong; Zhang, Tianyuan; US2003/232818; (2003); A1;,
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