Adding a certain compound to certain chemical reactions, such as: 60792-79-2, name is 2,2′-Oxybis(ethylamine) dihydrochloride, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 60792-79-2, Quality Control of 2,2′-Oxybis(ethylamine) dihydrochloride
A suspension of 0.2 M 2,2′-oxydiethylamine dihydrochloride (0.135 gm, 0.74 mmole) and 0.4 M DIEA (0.32 ml, 1.85 mmole) in 2.5 DMF was added to 4-morpholino-1,8-naphthalic anhydride (0.068 gm, 0.24 mmole) and heated at 150 C with microwave treatment under nitrogen for 12 minutes. The mixture was cooled, diluted with dichloromethane, washed with sat. NaHCO3, dried over MgSO4, and concentrated under vacuum to give N-aminoethylethoxy-4-morpholino-1,8 naphthalimide 9. 1H NMR (300 MHz, CDCl3): delta 8.59 (IH, d, J = 7.2 Hz); 8.53 (IH, d, J = 7.8 Hz); 8.42 (IH, d, J = 8.4 Hz); 7.70 (IH, t, J= 7.2 Hz); 7.25 (d, IH, J= 8.1 Hz); 4.43 (2H, t, J= 5.8 Hz); 4.02 (4H, m); 3.80 (2H, t, J= 6.0 Hz); 3.54 (2H, t, J = 5.2 Hz); 3.26 (4H, m); 2.81 (2H, t, ./ = 5.7 Hz).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,2′-Oxybis(ethylamine) dihydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GENENTECH, INC.; WO2006/60533; (2006); A2;,
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