Application of 27060-75-9,Some common heterocyclic compound, 27060-75-9, name is 1-Bromo-4-methoxy-2-methylbenzene, molecular formula is C8H9BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation process: Select a 100ml round bottom flask, add substrate 4-1 (1eq.),Tetrakis (triphenylphosphine) palladium (5%) and solvent ethylene glycol dimethyl ether to water 2: 1 (0.1M), after stirring at room temperature for twenty minutes,Add 2,4,6-trimethylphenylboronic acid (1.1 eq.) And sodium carbonate (3 eq.) And heat to 90 C for 36 h under reflux.Cool to room temperature, extract 3 times with ethyl acetate, collect the organic phase, dry over anhydrous sodium sulfate, spin-dry column chromatography, and use petroleum ether to ethyl acetate 40: 1 as eluent.A pale yellow solid was obtained with a yield of 86%.
The synthetic route of 27060-75-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nanjing Jianuolin Optoelectric Technology Co., Ltd.; Hang Xiaochun; Yin Junli; Liu Ruqing; (57 pag.)CN110615787; (2019); A;,
Ether – Wikipedia,
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