Adding a certain compound to certain chemical reactions, such as: 102-52-3, name is 1,1,3,3-Tetramethoxypropane, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 102-52-3, Computed Properties of C7H16O4
1. The starting precursor 2-bromomalonaldehydewas prepared using procedure given in literature [S. Trofimenko, J.Org. Chem. 28(11) (1963), 3243-3245.], [W.J. Tomsho, J.J. McGuire, K. Coward, Org. Biomol. Chem. 3(18) (2005)3388-3398.].To a 100 ml of aqueous solution of 1,1,3,3-tetramethoxypropane (1) (100g, 0.12 M) added concentrated HCl (4.3 ml) and stirred untilit forms homogeneous solution, the temperature of the reaction mixturemaintained was below 35 0C,then slowly added bromine (0.15 M) solution drop wise.After the completeaddition of bromine, stirring was continued for another 30 minutes. Then thereaction mixture was concentrated under vacuum, maintaining the temperature below50 0C until thick slurry was obtained. The obtained slurry waswashed with 200 ml cold water and 100 ml of cold dichloromethane and dried invacuum. Yield: 65%, MP: 148 0C (Lit: 146-147 0C [W.J. Tomsho, J.J. McGuire, K. Coward, Org. Biomol. Chem. 3(18) (2005)3388-3398.],148 0C [M.J. Grard, Compt. Rend. Acad. Sciences. 190 (1930)187:Ann.1930, 13, 336.].
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Reference:
Article; Yallur, Basappa Chanabasappa; Katrahalli, Umesha; Krishna, Panchangam Murali; Hadagali, Manjunatha Devagondahalli; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 222; (2019);,
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