Related Products of 7664-66-6, A common heterocyclic compound, 7664-66-6, name is 4-Isopropoxyaniline, molecular formula is C9H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of compound Al (0.5 g, 065 mmol) in toluene (10 rnL) and 4- Isopropoxyaniline (202 mg, 134 mmol) was added Ti(O-iPr)4 (190 mg, 0.66 rnmol). Themixture was stirred at 120 C overnight. The mixture was quenched with H20 (50 mL) and extracted with DCM (20 mE x 3). The combined organic layer was dried over potassium carbonate, filtered and concentrated. The residue was purified by silica gel column chromatography (DCM/MeOH == 15/1) to afford the crude products 304 and 30-2 (140 rng) as a brown solid .LC-MS: rnz 899.2 [M+H]?. To a solution of compounds 304 and 30-2 (137 mg. 015 rnmoi) in DCM (5 mE) was added DAST (24.5 rng, 0.15 mrnoi) at -78 C underN2. After stirred at -78 C for I Ii, the mixture was quenched with aqueous NaHCO3 and H20 and then extracted with DCM (30 mL x 3). i1e combined organic layer was dried over potassium carbonate, filtered and concentrated. The residue was purified by prep-HPLC to afford compound 30 (19 mg, yield14%) as yellow solid. Partial ?H NMR (CDCi3, 400 MHz): 6.93 (d, J::: Hz, 2H), 6.78-6.75 (m, 3H), 4.88 (s, 1H), 4.71-4.66 (in, 1H), 4.46-4.33 (rn, 2H), 4,32-4.29 (m, IH), 3.66-3.63 (m, 1H). 3.29-3.26 (m, 2H), 3.13-3.09 (in. 2H), 3.56-2.33 (rn, 3H); EC-MS: m/z 81.2[M+l-[[5.
The synthetic route of 7664-66-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AGRIMETIS, LLC; CALABRESE, Andrew; (110 pag.)WO2018/132288; (2018); A1;,
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