74137-36-3, name is 1,3-Dibromo-5-methoxybenzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 1,3-Dibromo-5-methoxybenzene
General procedure: Typically, TDPP (200 mg, 0.27 mmol), dibromobenzene derivatives 0.11 mmol, anhydrous Cs2CO3(200 mg, 0.61 mmol), PivOH (7.9 mg, 0.08 mmol), Pd2(dba)3 (4.00 mg, 1.5 mol%), tris(o-methoxyphenyl)phosphine (3.08 mg, 3 mol%) were successively added into a Schlenk tube. The tube was purged by three repetitions of vacuum and argon filling. Then, 5 mL anhydrous toluene was added via syringe.The reaction solution was deoxygenated using three freeze-vacuum-thaw cycles, and then rigorouslystirred at 100 C for 24 h under argon atmosphere. Removal of the toluene by rotary evaporatoraorded the crude product, which was then purified by chromatogragh column (CC) on silica gelusing a mixture of CH2Cl2 and hexane as eluent, giving the target molecules Ms1~9.
The synthetic route of 74137-36-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Liu, Hui; Zhang, Xiao-Feng; Cheng, Jing-Zhao; Zhong, Ai-Guo; Wen, He-Rui; Liu, Shi-Yong; Molecules; vol. 24; 9; (2019);,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem