Related Products of 873980-68-8,Some common heterocyclic compound, 873980-68-8, name is 4-Bromo-2-methoxy-5-methylaniline, molecular formula is C8H10BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 4-bromo-2-methoxy-5-methylaniline (4.0 g, 18 mmol) in MeOH (200 mL) was added KSCN (3.6 g, 37 mmol) and CUSO4 (14.9 g, 93 mmol). The reaction mixture was stirred at 80C overnight. The reaction mixture was quenched with aq. NH3 (7M, 200 mL), extracted with EtOAc (3 chi 200 mL) and washed with brine (200 mL). It was dried over Na2S04, filtered and concentrated. The residue was purified by silica gel chromatography (0%) to 10%) MeOH in DCM) to give 6-bromo-4-methoxy-7-methylbenzo[d]thiazol-2-amine (2.0 g, 39.5%) as a yellow solid. MS (ES+) C9H9BrN20S, requires: 272, found: 274 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-2-methoxy-5-methylaniline, its application will become more common.
Reference:
Patent; TESARO, INC.; JONES, Philip; CZAKO, Barbara; BURKE, Jason P.; CROSS, Jason; LEONARD, Paul Graham; TREMBLAY, Martin; MANDAL, Pijus; (232 pag.)WO2018/119387; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem