Reference of 101-55-3, A common heterocyclic compound, 101-55-3, name is 1-Bromo-4-phenoxybenzene, molecular formula is C12H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Suzuki-coupling reaction was carried out in a 25mL round bottom (RB) flask. Initially, RB was cleaned with water and then rinsed with acetone followed by drying at 60C in an oven for one hour. One mmol of bromobenzene and two mmol of phenylboronic acid were poured into RB. Subsequently, 2mL of toluene was inserted into the RB and closed with a rubber septum. The reaction solution was purged with N2 gas for 30min for the complete removal of air from the mixture. After that, RB was charged with 30mg of Ag/TiO2 photocatalyst, and the vessel was sealed with the rubber septum. The reaction mixture again purged with the N2 gas for the residual air and then irradiated with the 20W white LED (lambda ~ 420nm) for 24h. The sample was analyzed with TLC after every two-hour interval. The conversion and the yield were determined with GC-FID (Thermo equipped with Stabilwax w/Integra- Guard 30-m-long column), and confirmation was obtained by the 1H and 13C NMR of the pure samples.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Chen, Yuning; Feng, Li; Journal of Photochemistry and Photobiology B: Biology; vol. 205; (2020);,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem