Related Products of 60876-70-2,Some common heterocyclic compound, 60876-70-2, name is 1-Bromo-4-(tert-butoxy)benzene, molecular formula is C10H13BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 2 In a one-liter four-necked flask equipped with a stirrer and a reflux condenser, purged with nitrogen and dried was placed 24.3 g (1.0 mol.) of metallic magnesium flakes to which were added 10 ml of anhydrous diethyl ether and 2 ml of ethyl bromide. After confirming initiation of the reaction by bubbling on the surface of the metallic magnesium, a solution of 114.6 g (0.5 mol.) of p-tert-butoxybromobenzene in 400 ml of anhydrous diethyl ether was added dropwise at the refluxing temperature over approximately 1 hour, and stirring was continued for 5 hours to give p-tert-butoxyphenylmagnesium bromide.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-4-(tert-butoxy)benzene, its application will become more common.
Reference:
Patent; HOKKO CHEMICAL INDUSTRY CO., LTD; EP307106; (1989); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem