Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 366-99-4, name is 3-Fluoro-4-methoxyaniline, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C7H8FNO
To cyanuric chloride (28.84 g, 156.0 mmol) dissolved in acetone (200 mL) stirring at approximately 0-5 C, was added a solution of 3-fluoro-p-anisidine (22.16 g, 156.0 mmol) in acetone (200 mL) followed by the addition of NaOH (63 mL, 2.5 N, 156.0 mmol). The reaction mixture was allowed to stir at approximately 0-5 C for about 2 hours. The reaction mixture was then poured over crushed ice and neutralized with 10percent HCI(aq) and 5percent NaOH(aq). The resulting solid was collected by vacuum filtration, washed with water and dried overnight under vacuum. Column chromatography (silica gel, 70: 30 hexane: ethyl acetate) yielded light yellow solid compound 124 (29.6 g, 66percent); mp 134 C ; HPLC: Inertsil ODS-3V C18,40 : 30: 30[KH2PO4(O. 01M, pH 3.2) :CH30H : CH3CN], 264nm, Rt 20.3 min, 97.7 percent purity.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 366-99-4.
Reference:
Patent; REDDY US THERAPEUTICS, INC.; WO2004/26844; (2004); A1;,
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