Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 592-55-2, name is 1-Bromo-2-ethoxyethane, A new synthetic method of this compound is introduced below., category: ethers-buliding-blocks
Weigh 2,6-diaminopurine nucleoside (CAS No.: 2096-10-8) and dissolve 135.58kg in 1350L DMF.The reaction solution is cooled to 0 ± 2 C,Add NaH 29.10kg under argon protection.The temperature of the addition process was 0 C to 5 C, and the mixture was stirred at 0 C for 1 h.After the above reaction system naturally returns to room temperature,Drop into the system2-bromoethyl ethyl ether 73.64 kg,The reaction was stirred at room temperature.The reaction to the product no longer increases.The water quenching reaction was slowly added to the system at 0 ± 2 C.A 2 M HCl solution was slowly added to the system to adjust the pH to neutral.Concentrate in a vacuum at 65 C until it drops.The residual solid is crystallized in ethanol72.91kg of pale yellow solid,It is a 2′-EOE-2,6-diaminopurine nucleoside.The purity was 98.3%, and the yield was 42.8%.
The synthetic route of 592-55-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai Zhaowei Science And Technology Co., Ltd.; Shanghai Zhaowei Biological Engineering Co., Ltd.; Sun Bo; Li Xiqun; Zheng Weijian; Chen Hongyu; (10 pag.)CN108822174; (2018); A;,
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