Synthetic Route of 207226-31-1, These common heterocyclic compound, 207226-31-1, name is 1,3-Dibromo-5-(trifluoromethoxy)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 1,3-dibromo-5-(trifluoromethoxy)benzene (25 g, 78.15 mmol, 1 eq) in i-Pr2O (50 mL) was added n-BuLi (2.5 M, 32 mL, 1.02 eq) at -78C for 0.5 h, then acetone (7.9 g, 136 mmol, 10 mL, 1.74 eq) was added. The mixture was stirred at 20C for 2 h. The reaction mixture was poured into 100 mL of aqueous NH4Cl and the resulting mixture was stirred for 15 min. The organic phase was separated, dried over anhydrous Na2SO4, filtered and evaporated in vacuo to give a residue. The residue was purified by flash silica gel chromatography (ISCO; 80 g SepaFlash Silica Flash Column, Eluent of 0~1% Ethylacetate/Petroleum ethergradient 50 mL/min). The title compound (8 g, 26.75 mmol, 34% yield) was obtained as a yellow liquid. 1H NMR (400 MHz, DMSO-d6) delta ppm 1.94 (s, 6 H), 5.90 (s, 1 H), 7.91 – 8.01 (m, 2 H), 8.19 – 8.25 (m, 1 H).
The synthetic route of 207226-31-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SAINT LOUIS UNIVERSITY; INDALO THERAPUETICS, INC.; RUMINSKI, Peter, G.; GRIGGS, David, W.; SEIWERT, Scott; (155 pag.)WO2018/132268; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem