Application of 578-57-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 578-57-4, name is 1-Bromo-2-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.
n-BuLi (3.5 ml of a 1.6 M solution in hexane) was added with stirring at 0 C to a solution of 2-bromoanisole (1.0 g, 5.34 mmol) in dry hexane (10 ml) and the mixture was allowed to stir at room temperature. After 2 h stirring the n-butyl bromide formed in the reaction mixture was evaporated under reduced pressure without introduction of air. Dry THF (10 ml) was added followed by the addition of the finely ground selenium powder (0.42 g, 5.34 mmol) at 0 C. It was stirred for 4 h. It was poured to the ice-cooled saturated NaHCO3 solution and O2 gas was passed to the mixture in a moderate rate for 15 min. The compound was extracted with diethyl ether and dried with anhydrous Na2SO4. The solvent was evaporated to obtain yellow-colored solid. The compound was purified in flash chromatography using petroleum ether and ethyl acetate as solvent. It was characterized by NMR spectroscopy. Yield: 0.58 g (31%), 1H NMR (CDCl3), delta (ppm): 3.91 (s, 6H, OCH3), 6.80-6.83 (d, 2H, ArH), 6.85-6.89 (m, 2H, ArH), 7.19-7.23 (m, 2H, ArH), 7.53-7.55 (d, 2H, ArH); 13C NMR (CDCl3), delta (ppm): 56.4, 110.6, 119.1, 122.4, 128.6, 131.0, 157.3; 77Se NMR (CDCl3), delta (ppm): 328. ESI-MS: m/z: calcd for C14H13O2Se2 [M+Na]+: 396.9222; found: 397.0495.
The chemical industry reduces the impact on the environment during synthesis 1-Bromo-2-methoxybenzene. I believe this compound will play a more active role in future production and life.
Reference:
Article; Bhowmick, Debasish; Mugesh, Govindasamy; Tetrahedron; vol. 68; 51; (2012); p. 10550 – 10560,11;,
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