Adding a certain compound to certain chemical reactions, such as: 592-55-2, name is 1-Bromo-2-ethoxyethane, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 592-55-2, category: ethers-buliding-blocks
General procedure: To a solution of 2 (0.28 g, 1.132 mmol) in DMF (5 mL) was added potassium carbonate (0.438 g, 3.17 mmol) and 1-bromobutane (0.340 ml, 3.17 mmol). The mixture was heated at 90 C for 4 h, then cooled to rt and aq. HCl (0.2 M, 50 mL) was added. The mixture was extracted with CH2Cl2 (3 x 5 mL) and the combined organic layers were dried over MgSO4. Solvents were removed under reduced pressure and the residue was purified by silica gel chromatography using hexane:EtOAc (2:1) as eluent to give 3a (0.33 g, 91% yield).
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Reference:
Article; Slavik, Roger; Herde, Adrienne Mueller; Bieri, Daniel; Weber, Markus; Schibli, Roger; Kraemer, Stefanie D.; Ametamey, Simon M.; Mu, Linjing; European Journal of Medicinal Chemistry; vol. 92; (2015); p. 554 – 564;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem