Related Products of 854391-95-0,Some common heterocyclic compound, 854391-95-0, name is Bis(4-methoxybenzyl)amine hydrochloride, molecular formula is C16H20ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation of intermediate II-22; A mixture of 2-chloro-5-bromopyrimidine (1.0 g, 5.16 mmol), N-(4- methoxybenzyl)(4-methoxyphenyl)methanamine hydrochloride, (cas 854391-95- 0) (1.59 g, 5.418 mmol) and DIPEA (2.68 mL, 15.48 mmol) in dry dioxane (10 mL) was heated for 1 h at 160C under microwave irradiation. On cooling, the mixture was diluted with EtOAc (200 mL) and the organic phase was washed with saturated aqueous NaHC03 (50 mL), brine (50 mL), dried (MgS04) and the solvent removed in vacuo to give a residue that was purified by column chromatography (hexane/EtOAc mixtures -20:1 to 10:1- as eluent) to give desired product as a white solid (1.81 g, 85% yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Bis(4-methoxybenzyl)amine hydrochloride, its application will become more common.
Reference:
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); PASTOR FERNANDEZ, Joaquin; MARTINEZ GONZALEZ, Sonia; ALVAREZ ESCOBAR, Rosa Maria; RODRIGUEZ HERGUETA, Antonio; MARTIN HERNANDO, Jose Ignacio; RAMOS LIMA, Francisco, Javier; WO2011/89400; (2011); A1;,
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