Application of 22236-10-8,Some common heterocyclic compound, 22236-10-8, name is 4-(Difluoromethoxy)aniline, molecular formula is C7H7F2NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 2-[(fert-butyldimethylsilyloxy)methyl]-3-(4,6-dichloro-5- fluoropyrimidin-2-yl)-5-fluoropyrazolo[l,5-a]pyridine (102.0 mg, 0.23 mmol), 4- difluoromethoxy aniline (145.0 mg, 0.92 mmol) and ethanol (1 mL) was heated at 90C overnight. After cooling, the mixture was poured into ice- water to afford a solid. The solid was collected by filtration, followed by washing with water and hexane. The solid was dried under the vacuum to provide 2-[2-[(teri-butyldimethylsilyloxy)methyl]-5-fluoropyrazolo[l,5- a]pyridin-3-yl]-6-chloro-N-(4-difluoromethoxy)phenyl]-J-fluoropyrimidin-4-amine (a mixture of TBS protected and unprotected product).
The synthetic route of 22236-10-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PTC THERAPEUTICS, INC.; LEE, Chang-Sun; BAIAZITOV, Ramil; CAO, Liangxian; DAVIS, Thomas, W.; DU, Wu; LIU, Ronggang; MOON, Young-choon; PAGET, Steven, D.; REN, Hongyu; SYDORENKO, Nadiya; WILDE, Richard, Gerald; WO2014/81906; (2014); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem