Adding a certain compound to certain chemical reactions, such as: 2752-17-2, name is 2,2′-Oxydiethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2752-17-2, COA of Formula: C4H12N2O
Mixed nanosized TiO2-SiO2 oxide (0.27 g, 1.9 mmol) was added to a solution of acetoacetic ester (2) (3.75 g,28.8 mmol), 1,5-diamino-3-oxapentane (1a) (1.00 g, 9.6 mmol), and toluene (6 ml). The reaction mixture was stirred for 20 h at 90C. After the reaction was complete (TLC control, eluent 5:4:1 EtOAc-hexane-CHCl3), the nanosized oxide was separated by centrifugation, and toluene was removed by distillation. The obtained oil was purified by silica gel column chromatography, using CHCl3 as eluent, and dried under ambient conditions. Yield 2.33 g (74%), yellow oil. IR spectrum, nu, cm-1: 1141 (nuas, –Alk); 3291 (N-H); 1652,1505 (-O-N); 2930, 2978 (Alk-). 1H NMR spectrum,delta, ppm: 1.12-1.14 (6H, m, 2CH3); 1.90 (6H, s, 2CH3); 3.35-3.39 (4H, m, 2NCH2CH2); 3.51-3.55 (4H, m, 2NCH2CH2); 3.92-3.97 (4H, m, 232); 4.34-4.35 (2, m, 2); 8.59 (2H, s, 2NH). Found, %: 58.46; 8.43; N 8.69.16H28N2O5. Calculated, %: 58.51; 8.59; N 8.53.
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Reference:
Article; Radionova, Elena S.; Fedorova, Olga V.; Titova, Yulia A.; Rusinov, Gennady L.; Charushin, Valery N.; Chemistry of Heterocyclic Compounds; vol. 51; 5; (2015); p. 478 – 482; Khim. Geterotsikl. Soedin.; vol. 51; 5; (2015); p. 478 – 482,5;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem