Adding a certain compound to certain chemical reactions, such as: 888327-32-0, name is 4-Bromo-1-(difluoromethoxy)-2-methylbenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 888327-32-0, COA of Formula: C8H7BrF2O
EXAMPLE 71 Preparation of 2-Amino-5,5-bis-[4-(difluoromethoxy)-3-methylphenyl]-3-methyl-3,5-dihydro-4H- imidazol-4-one; Step 1 : bis(4-difluoromethoxy-3-methyl-phenyl)acetyleneIn a CEM snap top microwave vial were combined trimethylsilylacetylene (0.207 g, 2.11 mmol), 4-Bromo-1-difluoromethoxy-2-methyl-benzene (1.00 g, 4.22 mmol), tetrakis(triphenylphosphine)palladium (56 mg, 0.0485 mmol) and pyrrolidine (1 ml_, 12 mmol).The reaction vial was placed in a CEM Explorer microwave and irradiated for 30 minutes at 8O0C. The crude reaction mixture was poured directly onto silica gel and purified by column chromatography (hexanes) to yield 0.519 g of 1 ,1′-(1.2-ethynediyl)bis[4-difluoromethoxy-3- methylbenzene] as a clear oil (73%). 1H NMR (400 MHz, DMSO-cfe) delta ppm 2.24 (s, 6 H) 7.19 (d, 2 H) 7.26 (t, J=73.7 Hz, 2H) 7.44 (q,J=8.6, 2.1 Hz, 2 H) 7.51 (d, J=1.4 Hz, 2 H); MS (El) m/z 338 [M+.]
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-(difluoromethoxy)-2-methylbenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; WYETH; WO2008/115552; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem