Application of 33311-29-4,Some common heterocyclic compound, 33311-29-4, name is 4-(2-Methoxyethoxy)aniline, molecular formula is C9H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[00511] To a solution of tert-butyl 3-(2-chloro-5-nitropyrimidin-4-ylamino )phenylcarbamate(1) (430 mg, 1.37 mmol) in THF (10 mL) was added DIEA (530 mg, 4.1 mmol) and 4-(2-methoxyethoxy)aniline (39) (274 mg, 1.64 mmol) at r.t. under N2 atmosphere. The resultingmixture was stirred at r.t. overnight. The solvent was removed and the residue was purified byflash column chromatography (silica gel, 0 to 5% ethyl acetate in PE/DCM (1/1), with 0.5%TEA) to provide tert-butyl 3-(2-( 4-(2-methoxyethoxy)phenylamino )-5-nitropyrimidin-4-ylamino)phenylcarbamate (2) (559 mg, 96%) as a yellow solid. LC-MS (ESI) m/z (M+1) 497.1.
The synthetic route of 33311-29-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHARMACYCLICS, INC.; CHEN, Wei; YAN, Shunqi; LOURY, David, J.; FRYE, Leah, Lynn; GREENWOOD, Jeremy, Robert; SHELLEY, Mee, Yoo; WANG, Longcheng; WO2014/130693; (2014); A1;,
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