Extracurricular laboratory: Synthetic route of 39538-68-6

The synthetic route of 39538-68-6 has been constantly updated, and we look forward to future research findings.

39538-68-6, name is 2-Methoxy-4-methylaniline, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C8H11NO

General procedure: To a magnetically stirred solution of the selected aromatic amine (0.01 mol) in anhydrous dioxane (30 ml), succinic anhydride (0.01 mol) was added and the resulting suspension was refluxed for 24 h. Subsequently, the reaction mixture was cooled to room temperature. Subsequently, petroleum ether (200 mL) was added to the reaction mixture to yield the succinic monoamide derivatives (112-119, see Scheme 2) as white to grey solids. Using the same general procedure, the following compounds were synthesized.

The synthetic route of 39538-68-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Habash, Maha; Taha, Mutasem O.; Bioorganic and Medicinal Chemistry; vol. 19; 16; (2011); p. 4746 – 4771;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem