Synthetic Route of 2944-49-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2944-49-2 name is 1-Methoxy-2,3-dimethylbenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of the above crude product (2) (3.5g) in tetrachloromethane (C4Cl4) (100mL) at room temperature were added N-bromosuccinimide (NBS) (34.0g, 190.4mmol) and 2,2′-azobis(2-methylpropionitrile) (AIBN) (0.3g). The resulting reaction mixture was allowed to stir under reflux for 24h. After reaction completion, the reaction mixture was filtered and washed using the saturated NaHSO4 solution to remove the residual bromine. The organic layer was dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The residue was purified by flash chromatography to give a white solid (7.70 g, 72.4% in the two-step yield).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methoxy-2,3-dimethylbenzene, and friends who are interested can also refer to it.
Reference:
Article; Jin, Chaobin; Alenazy, Rawaf; Wang, Yinhu; Mowla, Rumana; Qin, Yinhui; Tan, Jin Quan Eugene; Modi, Natansh Deepak; Gu, Xinjie; Polyak, Steven W.; Venter, Henrietta; Ma, Shutao; Bioorganic and Medicinal Chemistry Letters; vol. 29; 7; (2019); p. 882 – 889;,
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