Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 366-99-4, name is 3-Fluoro-4-methoxyaniline, A new synthetic method of this compound is introduced below., Quality Control of 3-Fluoro-4-methoxyaniline
Acetone (11.6 g, 200 mmol), Acetic acid (1.8 g, 30 mmol), and Sodium triacetoxyborohydride (6.36 g, 30 mmol) were added to a solution of 3-Fluoro-4-methoxyaniline (2.82 g, 20 mmol) in DCM (120 mL) and the mixture was stirred at RT for 12 hr. Water was added to quench the reaction and the mixture was extracted with DCM. The solvent was removed under and the residue was purified by silica gel chromatography to afford 3-Fluoro-N-isopropyl-4-methoxyaniline (2.90 g, 79percent yield). 1H NMR (400 MHz, CDC13) delta ppm 6.84 (dd, J= 9.5, 8.7 Hz, 1H), 6.41 (dd, J= 13.5, 2.7 Hz, 1H), 6.33- 6.27(m, 1H), 3.83 (s, 3H), 3.54-3.52(m, 1H), 3.28 (s, 1H), 1.21 (d, J= 6.3 Hz, 6H).
The synthetic route of 366-99-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JIANGSU ASCENTAGE BIOMED DEVELOPMENT INC.; CHEN, Jianyong; ZHOU, Yunlong; WANG, Shaomeng; GUO, Ming; YANG, Dajun; JIAO, Lingling; JING, Yu; QIAN, Xu; LIU, Liu; BAI, Longchuan; YANG, Chao-Yie; MCEACHERN, Donna; WO2015/127629; (2015); A1;,
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