Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 54314-84-0, name is ((3-Bromopropoxy)methyl)benzene, A new synthetic method of this compound is introduced below., HPLC of Formula: C10H13BrO
Compound 38E: Methyl 1-[3-(benzyloxy)propyl]-4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)- 1 /-/-pyrrole-2-carboxylate.A mixture of methyl 4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)-1 H-pyrrole-2- carboxylate (Compound 38F, 600 mg, 2.39 mmol) and 1-bromo-3-benzyloxypropane (575 mg, 2.51 mmol) in DMF (2.19 mL) was charged with cesium carbonate (778 mg, 2.39 mmol). The reaction mixture was allowed to stir at 70 °C for 16 hrs. The reaction mixture was diluted with water and then extracted with EtOAc (2x). The organic layer was washed with water (2x), brine (1 x), dried over Na2S04, filtered, concentrated in vacuo and purified using a Teledyne ISCO Combiflash.(R). Rf system [0–> 4percent Ethanol in DCM] to afford 442mg of the title compound (46percent). 1H NMR (400 MHz, CD3OD) delta 7.26 – 7.37 (m, 5H), 7.25 (d, J = 1 .8 Hz, 1 H), 7.17 (d, J = 1.8 Hz, 1 H), 4.45 (s, 2H), 4.42 (t, J = 6.8 Hz, 2H), 3.78 (s, 3H), 3.38 (t, J = 5.9 Hz, 2H), 2.01 (t, J = 6.2 Hz, 2H), 1 .31 (s, 12H). MS (ESI): m/z 440.59 [M+H]+. UPLC: tR = 1.60 min (UPLC-TOF: polar_2 min).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; OSI PHARMACEUTICALS, LLC; CREW, Andrew, P.; DONG, Hanqing; FERRARO, Caterina; SHERMAN, Dan; SIU, Kam, W.; WO2012/74951; (2012); A1;,
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Ether | (C2H5)2O – PubChem