In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 588-96-5 as follows. Recommanded Product: p-Bromophenetole
To a solution of 2R-allyl-3S-hydroxy-succinic acid diisopropylester (4.79 g, 18.5 MMOL), 4-bromo phenetole (3.19 ML, 22.2 mmol, 1.2 eq. ) and NEt3 (6.22 ML, 44.6 mmol, 2.4 eq. ) in CH3CN (40 ml), was added a sonicated (for 2 min) suspension of P (O-TOL) 3 (0.57 g, 2.22 mmol, 0.1 eq. ) and Pd (OAC) 2 (209 mg, 5%) in CH3CN (5 ML). The reaction mixture was heated to reflux for 2 hrs. CH3CN was removed under vacuo. The crude was extracted with AcOEt (3 X 200 ML), washed with water (50 ML) and with brine (50 ML). A purification by flash chromatography afforded the desired 2R- [3- (4-ETHOXY-PHENYL)-ALLYL]-3S- hydroxy-succinic acid diisopropyl ester (5.92 g, 84% yield).
According to the analysis of related databases, 588-96-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; VERNALIS (OXFORD) LIMITED; LABORATOIRES SERONO S.A.; WO2005/19194; (2005); A1;,
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