Related Products of 27060-75-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 27060-75-9, name is 1-Bromo-4-methoxy-2-methylbenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
(Hereinafter, sometimes, referred to as the compound (1).) Preparation Mg 165 mg of (2.0 eq) and charged with THF 10 mL reactor under a nitrogen atmosphere, 2-bromo-5-methoxy-toluene 1.37g of (2.0 eq) in addition, the mixture was stirred for 5 hours at 60 . The reaction mixture was cooled in an ice bath, was obtained according to Example 1-2 3,6-bis {[t-butyl (dimethyl) silyl] oxy}-9H-xanthene-9-one 1.50g of (3.40 mmol) It was added dropwise a THF solution 10 mL, and stirred for 30 minutes and returned to room temperature. Then, slowly adding 2N aqueous hydrochloric acid 20mL the reaction mixture under ice-cooling, followed by stirring at room temperature for 15 hours, added with chloroform, the organic layer was separated, saturated aqueous NaHCO3, washed sequentially with saturated aqueous sodium chloride solution. After drying over MgSO4, washing the crystalline residue obtained and the solvent was evaporated under reduced pressure with diethyl etherBy to give 6-hydroxy-9- (4-methoxy-2-methylphenyl)-3H-xanthene-3-one 0.77g (68% yield) as an orange crystals.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-methoxy-2-methylbenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; HARADA, KOICHIRO; TAKAKU, TOMOYUKI; TAKEUCHI, HAYATO; (13 pag.)JP2015/205841; (2015); A;,
Ether – Wikipedia,
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