Adding a certain compound to certain chemical reactions, such as: 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 74654-07-2, Recommanded Product: 74654-07-2
To a solution of N-((S)-2-((S)-3-aminopyrrolidin-l -yl)-l -phenylethyl)-2-(3,4- dichlorophenyl)-N-methylacetamide (150 mg, 0.37 mmol) in acetonitrile (3 mL) was added mPEG3-NH2 (66 mg, 0.407 mmol) and potassium carbonate (153 mg, 1.1 1 mmol). The mixture was heated to 50 C for 18 hours. After 18 hours, the mixture was concentrated under vacuum and the resulting crude was dissolved in ethyl acetate (10 mL). The organic layer, after washes with aq. ammonium chloride (10 mL), water (10 mL) and brine (10 mL), was dried over anhydrous sodium sulfate and concentrated under vacuum to give the crude compound. The crude compound post purification by column chromatography afforded 2- (3,4-dichlorophenyl)-N-((5)-2-((,S)-3-((2-(2-(2- methoxyethoxy)ethoxy)ethyl)amino)pyrrolidin-l -yl)-l -phenylethyl)-N-methylacetamide as the free base (0.081 g, 40% yield). NMR (500 MHz, CDC13): delta 7.61 (m, 1 H), 7.40-7.27 (m, 7H), 5.22 (m, 1 H), 4.20 (t, 2H), 3.70-3.45 (m, 10H), 3.32 (s, 3H), 3.24 (m, 2H), 3.04 (m, 1 H), 2.79-2.72 (m, 2H), 2.62 (s, 3H), 2.46-2.30 (m, 4H), 1.54- 1 .79 (m, 2H); MS (EI) for C28H39C12N304: 553 (MH+).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NEKTAR THERAPEUTICS; ANAND, Neel, K.; DUARTE, Franco, J.; ZHANG, Wen; REN, Zhongxu; WO2014/210436; (2014); A2;,
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