Synthetic Route of 437-82-1, A common heterocyclic compound, 437-82-1, name is 2,6-Difluoroanisole, molecular formula is C7H6F2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5 g (34.7 mmol) of 2,6-difluoroanisole and 2.62 g (40 mmol) of cyclopropylnitrile are added in 100 ml of toluene. At room temperature, 77 ml of a 0.5 M solution of KHMDS in toluene is added in drops. The reaction mixture is heated slightly. After stirring overnight at room temperature, water and ethyl acetate are added. It is shaken with 10% sulfuric acid, and the organic phase is separated. After repeated shaking of the aqueous phase with ethyl acetate, the combined organic extracts are washed with brine. After drying on sodium sulfate, it is filtered off, and the solvent is spun off. After chromatography on silica gel (mobile solvent: ethyl acetate/hexane), 2.53 g (38.2%) of the desired compound is obtained.
The synthetic route of 437-82-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Schmees, Norbert; Lehmann, Manfred; Rehwinkel, Hartmut; Strehike, Peter; Jaroch, Stefan; Schaecke, Heike; Schottelius, Amdt J.G.; US2004/209875; (2004); A1;,
Ether – Wikipedia,
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