Reference of 1663-61-2,Some common heterocyclic compound, 1663-61-2, name is (Triethoxymethyl)benzene, molecular formula is C13H20O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a stirred solution of malononitrile (10mmol, 1.0eq) in acetic anhydride (1.5mL) was added 1,1,1-triethoxypropane and its derivatives (30mmol, 3.0eq). The solution was stirred for 15 h at reflux, cooled, and poured into water. The mixture was extracted with ethyl acetate (200mL), washed with water, brine and dried over sodium sulfate. After concentrated under vacuum, the crude product was purified using silica gel chromatography to give the title compounds. The compounds ware directly used in the next step.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (Triethoxymethyl)benzene, its application will become more common.
Reference:
Article; Fang, Zhen; Wang, Tian-qi; Li, Hui; Zhang, Guo; Wu, Xiao-ai; Yang, Li; Peng, Yu-lan; Zou, Jun; Li, Lin-li; Xiang, Rong; Yang, Sheng-yong; Bioorganic and Medicinal Chemistry Letters; vol. 27; 14; (2017); p. 3201 – 3204;,
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