Some common heterocyclic compound, 39021-83-5, name is 1,4-Dimethoxy-2,3-dimethylbenzene, molecular formula is C10H14O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1,4-Dimethoxy-2,3-dimethylbenzene
The compound 72 (5 g, 30.1 mmol) was dissolved in TFA (50 mL) and hexamine (4.7 g, 33.1 mmol) was added to the resulting solution. The reaction mixture was refluxed under dry conditions for 2 hours. The TFA was evaporated under reduced pressure and the residue was dissolved in EtOAc (100 mL) . and the The resulting organic solution was washed with water (3×50 mL) and then dried over Na2SO4. The solvent organic phase was evaporated concentrated in vacuum and the residue was subjected to silica gel column chromatography (petroleum ether/EtOAc 20: 1 to 10: 1) to giveproduct 73 (3.1 g, 53) as a white solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 39021-83-5, its application will become more common.
Reference:
Patent; XW LABORATORIES, INC.; XW LABORATORIES INC.; XIANG, Jia-Ning; QI, Zude; NING, Dezheng; LIU, Xianbo; (152 pag.)WO2019/33330; (2019); A1;,
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