Related Products of 13321-74-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13321-74-9, name is 4-Bromo-2,5-dimethoxytoluene, This compound has unique chemical properties. The synthetic route is as follows.
To a stirred solution of 1-bromo-2,5-dimethoxy-4-methylbenzene (12) (1.98 g, 8.58 mmol) and (R)-3-acryloyl-4-phenyloxazolidin-2-one (13) (1.86 g, 8.58 mmol) in MeCN/H2O (10:1, 40 mL) were added Pd(OAc)2 (192.58 mg, 0.86 mmol), (o-tol)3P (522 mg, 1.7 mmol), and Et3N (2.391 mL, 0.017 mmol) at rt, and allowed to warm to 80 C. After being stirred at the same temperature for 2 h, the resultant mixture was added water and CH2Cl2 and then extracted with CH2Cl2. The combined extracts were washed with brine, the residue upon workup was chromatographed on silica gel with hexane/AcOEt (4:1 v/v) as a eluent to give a enone 5 (2.564 g, 81%) as a yellow solid; inlMMLBox -5.17 (c 0.95 in CHCl3); mp 55.5-59.5 C; IR (neat) 2958, 1781, 1705, 1505, 1465, 1384, 1209, 1045 cm-1; 1H NMR (400 MHz, CDCl3) delta 2.24 (3H, s), 3.82 (3H, s), 3.82 (3H, s), 4.31 (1H, dd, J=8.8 and 4.0 Hz), 4.73 (1H, t, J=8.8 Hz), 5.57 (1H, dd, J=8.8 and 4.0 Hz), 6.72 (1H, s), 7.02 (1H, s), 7.30-7.39 (5H, m), 7.93 (1H, d, J=16.0 Hz), 8.12 (1H, d, J=16.0 Hz); 13C NMR (100 MHz, CDCl3) delta 16.7 (CH3), 55.8 (CH3), 56.0 (CH3), 57.8 (CH3), 69.8 (CH2), 109.8 (CH), 114.4 (CH), 115.7 (CH), 121.1 (Cq), 125.9 (CH), 128.5 (CH), 129.0 (CH), 131.8 (Cq), 139.3 (Cq), 142.0 (CH), 151.7 (Cq), 153.0 (Cq), 153.9 (Cq), 165.2 (Cq); HRMS (ESI) calcd for C21H21NO5Na [M+Na]+ 390.1317, found 390.1310.
The chemical industry reduces the impact on the environment during synthesis 4-Bromo-2,5-dimethoxytoluene. I believe this compound will play a more active role in future production and life.
Reference:
Article; Miyawaki, Akari; Osaka, Mayu; Kanematsu, Makoto; Yoshida, Masahiro; Shishido, Kozo; Tetrahedron; vol. 67; 35; (2011); p. 6753 – 6761;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem