Synthetic Route of 5111-65-9, These common heterocyclic compound, 5111-65-9, name is 2-Bromo-6-methoxynaphthalene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Reference Example 22 Preparation of 2-formyl-6-methoxynaphthalene n-BuLi in hexane (1.59M, 125 ml) was added dropwise to a solution of 2-bromo-6-methoxynaphthalene (42.27 g) in THF (600 ml) at -78 C. and was stirred at -78+ C. for 30 minutes. To the mixture was added DMF (28 ml), and the whole was allowed to warm to room temperature. The reaction mixture was acidified with HCl and extracted with ethyl acetate. The extract was dried and concentrated to give the titled compound (32.31 g) as a colorless solid. 1H-NMR (CDCl3) delta: 3.96 (3H, s), 7.15-7.30 (2H,m), 7.75-7.97(3H,m), 8.26 (1H,s), 10.10 (1H,s). IR (KBr): 2841, 1688, 1624, 1480, 1269, 1028, 856 cm-1.
The synthetic route of 5111-65-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Takeda Chemical Industries, Ltd.; US6420375; (2002); B1;,
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