Application of 7252-83-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7252-83-7 as follows.
Step 1: Methyl 2-bromo-3-cyclohexyl-l-(2.2-dimethoxyethyl)-lH-indole-6-carboxylate; To a stirred solution of methyl 2-bromo-3-cyclohexyl-lH-indole-6-carboxylate (prepared as described in published International patent application WO2004/087714) (0.2 M, 1 eq.) in DMF at RT was added NaH (60 % dispersion in mineral oil, 1.75 eq). After Ih, KI (8 mol %) and bromoacetaldehyde dimethyl acetal (2.5 eq) were added and the reaction heated at 80 0C for 17 h. After cooling to RT, the reaction was quenched by addition of aqueous HCl (IN) and extracted into EtOAc (x3). The combined organics were washed with HCl (IN), H2O and brine before being dried (Na2SO4), filtered and concentrated in vacuo. Purification by flash column chromatography (Biotage, 5-10 % EtOAc/PE gradient) gave the title compound as a white solid (79 %); MS (ES+) m/z 446 (M+H)+, 448 (M+H)+.
According to the analysis of related databases, 7252-83-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA; WO2006/46030; (2006); A2;,
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