New downstream synthetic route of 102-52-3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1,3,3-Tetramethoxypropane, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 102-52-3, name is 1,1,3,3-Tetramethoxypropane, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 102-52-3, Safety of 1,1,3,3-Tetramethoxypropane

1,1,3,3-Tetramethoxypropan (0.16 g, 1.0 mmol) was added dropwise to a stirred solution of 4-hydrazinyl-6-methyl-2-(pyridin-2-yl)pyrimidine (0.20 g, 1.0 mmol) in a mixture of water (2 ml) and concentrated HCl acid (0.4 ml) at 40 C. The reaction mixture was stirred for 1 h, cooled down, diluted with CHCl3 and washed with the saturated solution of NaHCO3, then with water, and dried over MgSO4. After CDCl3 removal under reduced pressure the residue crystallized. Yield: 0.18 g (75%), m.p. 97 C (from hexane). Anal. Calc. for C13H11N5: C, 65.77; H, 4.62; N, 29.56. Found: C, 65.82; H, 4.64; N, 29.54%. 1H NMR (CDCl3, 300.15 MHz) delta (ppm): 8.85 (ddd, 1H, J = 4.7, 1.8, 1.0 Hz, 6-Hpyridine), 8.76 (dd, 1H, J = 2.7, 0.4 Hz, 5-Hpyrazole), 8.52 (dt, 1H, J = 7.7, 1.0 Hz, 3-Hpyridine), 7.86 (dt, 1H, J = 7.7, 1.8 Hz, 4-Hpyridine), 7.79 (s, 1H, 5-Hpyrimidine), 7.80-7,78 (m, 1H, 3-Hpyrazole), 7.40 (ddd, 1H, J = 7.7, 4.7, 1.0 Hz, 5-Hpyridine), 6.51 (dd, 1H, J = 2.7, 1.6 Hz, 4-Hpyrazole), 2.72 (s, 3H, Me). IR (KBr pellet, nu cm-1): 3161w, 3130w, 3076m, 3055w, 3008w, 2918w, 1587vs, 1560vs, 1523s, 1458vs, 1441s, 1394s, 1379s, 1225m, 1149w, 1115w, 1037m, 985w, 951m, 914m, 862m, 810m, 760s, 740m, 679w, 604m, 584w.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1,3,3-Tetramethoxypropane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Bushuev, Mark B.; Gatilov, Yuri V.; Nikolaenkova, Elena B.; Vasiliev, Vladimir G.; Krivopalov, Viktor P.; Inorganica Chimica Acta; vol. 395; (2013); p. 95 – 103;,
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