Sources of common compounds: 126-38-5

Adding a certain compound to certain chemical reactions, such as: 126-38-5, name is 1-Bromo-2,2-dimethoxypropane, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 126-38-5, Recommanded Product: 1-Bromo-2,2-dimethoxypropane

A mixture of (R)-tert-butyl 3-((R)-(3-chlorophenyl)(hydroxy)methyl)piperidine- 1-carboxylate (0.2234 g, 0.68 mmol), 60% NaH (1.460 g, 36.5 mmol), and 1-bromo- 2,2-dimethoxypropane (7.760 g, 42.4 mmol) in THF (20 mL) was heated at 80 C for 3 d and then cooled to rt. The reaction mixture was then quenched with water, extracted with ethyl acetate (3x), and dried over Na2SO4. After the solvent was evaporated under reduced pressure, the crude product (R)-tert-buty 3-((R)-(3-chlorophenyl)(2,2- dimethoxypropoxy)methyl)piperidine-1-carboxylate was directly used in the next step without further purification.

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Reference:
Patent; VITAE PHARMACEUTICALS, INC.; WO2007/70201; (2007); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem